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Dr Jo Ingram - Research Fellow
Institute of Medical and Biological Engineering
Institute of Molecular and Cellular Biology
Faculty of Biological Sciences
The University of Leeds
LS2 9JT, UK
Tel: [+44] (0)113 343 5651, Fax: [+44] (0)113 343 3167
E-mail: j.h.ingram@leeds.ac.uk, Room: Garstang 7.63
Ultrasonic modification of soft tissue matrices for enhanced recellularisation of tissue engineered biomaterials
EPSRC Portfolio Partnership
Supervisor: Professor Eileen Ingham, Professor John Fisher
Modification of natural tissue matrices to implant as acellular constructs, or to recellularise in vitro and re-implant as living tissues is an attractive approach for soft tissue replacements such as ligaments, tendons, skin and heart valves. Penetration of viable cells throughout the matrix during recellularisation in vitro or in vivo remains a challenge. We propose to investigate the use of ultrasonic energy to modify the structure of soft tissue matrices to enhance cellular penetration and recellularisation. A range of ultrasonic energy levels and doses will be studied and the resulting changes in tissue structure, cellular penetration and rate of recellularisation investigated under passive and biomechanically active conditions in vitro.
Soft tissue recellularisation
EPSRC Portfolio Partnership
Supervisor: Professor Eileen Ingham, Professor John Fisher
The aim of this project is to modify a decellularised soft tissue scaffold in order to allow complete recellularisation of the scaffold by appropriate cells.
Concentrating on using the patella tendon to reconstruct damaged anterior cruciate ligaments we will also investigate the role of mechanical stimulation on remodelling of decellularised scaffolds by cells.
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